NEXT GENERATION PROTEOMICS WITH DRUG SENSITIVITY SCREENING IDENTIFIES SUB-CLONES INFORMING THERAPEUTIC AND DRUG DEVELOPMENT STRATEGIES FOR MULTIPLE MYELOMA PATIENTS

Abstract With the introduction of novel therapeutic agents, survival in Multiple Myeloma (MM) has increased in recent years.However, drug-resistant clones inevitably arise and lead to disease progression and death.The current International Myeloma Working Group response criteria are broad and make it difficult to clearly designate resistant and res

An upscaling method for estimating macrofracture toughness by nanoindentation results was proposed in this study.Grid nanoindentation tests were conducted on sandstone samples motovox scooter parts to obtain micromechanical properties of indents, including elastic modulus, hardness, and stiffness.Multifactor cluster analysis was then carried out to